FLANKING V and J SEQUENCES OF COMPLEMENTARY DETERMING REGION 3 OF T CELL RECEPTOR (TCR) δ1 (CDR3δ1) DETERMINE THE STRUCTURE AND FUNCTION OF TCRγ4δ1*
نویسندگان
چکیده
Yan Jiang (姜燕), Yang Guo (郭阳), Xueyan Xi (郗雪艳), Lianxian Cui (崔莲仙), and Wei He (何 维) From the Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, National Key Laboratory of Medical Molecular Biology, Beijing, China Address correspondence to: Wei He, MD, Dept. of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, 5 Dong Dan San Tiao, Beijing 100005, China. Tel.: 86-10-68792233; Fax: 86-10-68792233; E-mail: hewei @moh.gov.cn
منابع مشابه
Flanking V and J Sequences of Complementary Determining Region 3 of T Cell Receptor (TCR) δ1 (CDR3δ1) Determine the Structure and Function of TCRγ4δ1*
The γδ T cell receptor (TCR) differs from immunoglobulin and αβ TCR in its overall binding mode. In human, genes δ1, δ2, and δ3 are used for TCRδ chains. Previously, we have studied antigen binding determinants of TCRδ2 derived from dominant γδ T cells residing in peripheral blood. In this study we have investigated the critical determinants for antigen recognition and TCR function in TCRδ1 ori...
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